描述

QUININE SULFATE TABLET 300MG

Indications:

For the treatment of chloroquine resistant falciparum malaria in adults and children aged 5 years or older (and ≥ 20kg)

Dosage and administration：

Posology

Treatment of chloroquine resistant falciparum malaria

Adults (including the elderly) and children aged 12 years and over: 600mg of quinine sulfate given every 8 hours for 7 days. The dose may depend upon the size of the patient, severity of infection, and evidence of renal or liver disease (when the intervals should be increased), due to a prolonged half-life of the drug.

Paediatric population

Treatment of chloroquine resistant falciparum malaria

The dosage regimen for children by mouth is 10mg of quinine sulfate per kg body weight given every 8 hours for 7 days. Quinine sulfate 200mg tablets are not suitable for children weighing less than 20kg or less than 5 years old.

Method of administration

For oral administration.

Contraindications:

– Hypersensitivity to the active substance or to any of the excipients

– Tinnitus

– Optic neuritis

– Haemoglobinuria

– Myasthenia gravis (quinine may cause severe respiratory distress and dysphagia in these patients)

Precautions:

Chinchonism

Administration of quinine may give rise to cinchonism, which is generally more severe in overdose, but may also occur in normal therapeutic doses.

Hypersensitivity

Hypersensitivity to quinine may also occur with symptoms of cinchonism together with urticaria, flushing, pruritus, rash, fever, angioedema, dyspnoea and asthma.

Cardiac disorders

Quinine should be used with caution in patients with atrial fibrillation, conduction defects and heart block or other serious heart disease.

Glucose-6-Phosphate Dehydrogenase (G-6-PD) Deficiency

The administration of quinine to a patient who has previously been suffering from a chronic and inadequately controlled malarial infection may precipitate an attack of Blackwater fever.

Quinine should not be withheld from pregnant women who have life threatening malaria.

Treatment should be monitored in all patients in case signs of resistance develop.

Thrombocytopenia

Quinine may cause unpredictable serious and life-threatening thrombocytopenia, which is thought to be an idiosyncratic hypersensitivity reaction.

Drug interactions:

Caution is advised when administering quinine with drugs which could prolong the QT interval.

Antiarrhythmics

Antibacterials

Anticoagulants

Antihistamines

Antimalarials

Antipsychotics

Hypoglycaemics

Suxamethonium

Ulcer-healing drugs

Anti-epileptics

Storage:

Do not store above 25°C.